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Oral terbutaline dosage in preterm pregnancy

118 30.09.2019
Cornelia R. Graves, MD Dr. Although short-term tocolysis usually is safe, certain agents and scenarios may increase the risk of harm. Here, four cases involving serious complications. C ASE 1: Preterm labor with cervical changes. She is given subcutaneous terbutaline to suppress her contractions.
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Preterm Labor: Diagnosis and Treatment

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Terbutaline Dosage Guide with Precautions -

Food and Drug Administration FDA is warning the public that injectable terbutaline should not be used in pregnant women for prevention or prolonged treatment beyond hours of preterm labor in either the hospital or outpatient setting because of the potential for serious maternal heart problems and death. The agency is requiring the addition of a Boxed Warning and Contraindication to the terbutaline injection label to warn against this use. In addition, oral terbutaline should not be used for prevention or any treatment of preterm labor because it has not been shown to be effective and has similar safety concerns. The agency is requiring the addition of a Boxed Warning and Contraindication to the terbutaline tablet label to warn against this use. Terbutaline is approved to prevent and treat bronchospasm narrowing of airways associated with asthma, bronchitis, and emphysema. The drug is sometimes used off-label an unapproved use for acute obstetric uses, including treating preterm labor and treating uterine hyperstimulation. Terbutaline has also been used off-label over longer periods of time in an attempt to prevent recurrent preterm labor.
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Terbutaline Pregnancy and Breastfeeding Warnings

European Journal of Clinical Pharmacology. Terbutaline in plasma was determined in three groups of women by gas chromatography-mass spectrometry. Eight women received a single i. There was a subsequent decrease in mean terminal half-life from 5.
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Drug information provided by: IBM Micromedex. Terbutaline is used to prevent bronchospasm in patients 12 years of age and older with asthma, bronchitis, emphysema, and other lung diseases. Terbutaline belongs to the family of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes air passages of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

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